SMTP Timing out 10060 error

Hello, a client is using a piece of software that uses SMTP relay to send mail. This has stopped working on one of the machines, since installation of Comodo. I think it is a firewall issue, however I can not see where it is blocked. Any suggestions?

Hello @cccservices ,

Support team will get in touch with you via email to get more information regarding the issue.
Please do reply at your convenience.

Thanks.